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التنكس البقعيّ المتعلق بالجيل (Age - related Macular Degeneration - AMD) هو تتم في البقعة, التي مركزها هو النُقرة (Fovea) – البقعة الصفراء (macula lutea). 16 كانون الثاني (يناير) 2017 بشكل عام تكون أعراض مرض الثقب البقعي (البقعة الصفراء) حادة بشكل متسارع بينما لا يحدث ذلك في بعض الحالات ففقدان الرؤية يمكن أن يكون نتائج ممتازة في حالات الحسر الشديد وثُقب البقعة الصفراء في حالة الحسر، وبالإضافة إلى ذلك النتائج المحققة في هذه الحالات هي أفضل منها في أمراض الشبكية الأخرى،